Hydrochloride methanol → HCID 23156590, compound

HRID 228915Notes

Reaction equation

HRID 228915 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH2:14][CH2:15][CH2:16][N:17]1[CH2:22][CH2:21][O:20][CH2:19][CH2:18]1)[N:9]=[CH:8][CH:7]=[C:6]2[O:23][C:24]1[CH:29]=[C:28]([CH3:30])[C:27]([CH3:31])=[CH:26][C:25]=1[C:32](=[O:34])[CH3:33].[ClH:35].CO>>[ClH:35].[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH2:14][CH2:15][CH2:16][N:17]1[CH2:18][CH2:19][O:20][CH2:21][CH2:22]1)[N:9]=[CH:8][CH:7]=[C:6]2[O:23][C:24]1[CH:29]=[C:28]([CH3:30])[C:27]([CH3:31])=[CH:26][C:25]=1[C:32](=[O:34])[CH3:33]

Participants

3

Reactant 2

HCID 21893726Hydrochloride methanolHCID 23156591HCID 23156591, compound2×

Product 1

HCID 23156590HCID 23156590, compoundYield 100%

Procedure

1-{2-[6-Methoxy-7-(3-morpholin-4-yl-propoxy)-quinolin-4-yloxy]-4,5-dimethyl-phenyl}-ethanone (compound 319) (344 mg) was dissolved in a hydrochloric acid-methanol solution (10 ml), and the solution was stirred at room temperature overnight. The solvent was removed by distillation under the reduced pressure, and the residue was washed with ethyl acetate and was dried under the reduced pressure to give the title compound (398 mg, yield 100%).

Workup

  1. customThe solvent was removed by distillation under the reduced pressure
  2. washthe residue was washed with ethyl acetate
  3. customwas dried under the reduced pressure

Sources & evidence

ORD record
ord-9aa32a274a234ed09239a4f910ecc219
Source dataset
uspto-grants-2009_07
Patent number
US07560558B2

Reaction notes

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