反应详情

A mixture of 1-4 (5.0 g, 24.8 mmol), 2-amino-3-formylpyridine 1-5 [3.6 g, 29.8 mmol; for preparation see J. Org. Chem., 48: 3401 (1983)] and 20% KOH (1 ml) in absolute ethanol (100 mL) was heated at reflux for 8 h. Following evaporative removal of the solvent, the residue was chromatographed (silica gel, 70:28:2 chloroform/ethyl acetate/methanol) to give 1-6 as a yellow oil.

1. temperaturewas heated
2. temperatureat reflux for 8 h
3. customremoval of the solvent
4. customthe residue was chromatographed (silica gel, 70:28:2 chloroform/ethyl acetate/methanol)