Acetic Acid → N-(2-cyano-3-methylbutanoyl)urea

HRID 2289181Notes

Reaction equation

HRID 2289181 reaction equation
[C:1]([CH2:3][C:4]([NH:6][C:7]([NH2:9])=[O:8])=[O:5])#[N:2].[C:10](O)(=O)[CH3:11].[C:14]([O-])(=O)C.[NH4+]>CC(C)=O>[C:1]([CH:3]([CH:10]([CH3:11])[CH3:14])[C:4]([NH:6][C:7]([NH2:9])=[O:8])=[O:5])#[N:2]

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 74055Acetamide, N-(aminocarbonyl)-2-cyano-HCID 517165Ammonium Acetate

Product 1

HCID 9793952N-(2-cyano-3-methylbutanoyl)urea

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent2×

Procedure

When acetone is used as a reaction solvent, the production method is almost the same as the one mentioned above, wherein cyanoacetylurea is suspended or dissolved in acetone, and acetic acid and ammonium acetate are added to allow reaction under reducing conditions to give N-(2-cyano-3-methylbutanoyl)urea. Preferably, the reaction is carried out in the presence of a reduction catalyst. The termination of the reaction can be confirmed and the objective product can be isolated after the reaction, according to the above-mentioned methods.

Workup

  1. customreaction under reducing conditions

Sources & evidence

ORD record
ord-d4382fdaadd64b3aafaaf1833632d976
Source dataset
uspto-grants-2000_07
Patent number
US06090970

Reaction notes

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