反应详情

温度

125 °C

2-Iodo-6-picolin-3-ol (10 g), 4-chloro-7-benzyloxy-6-methoxyquinoline (6.8 g), and 4-(N,N-dimethylamino)-pyridine (12.2 g) were dissolved in 1,2-dichlorobenzene (400 ml) to prepare a solution, and the mixture was stirred at 125° C. overnight. The reaction solution was cooled to room temperature, and the solvent was then removed by distillation under the reduced pressure. Water was added to the residue, the mixture was extracted with chloroform, and the chloroform layer was then washed with water and was dried over anhydrous sodium sulfate. The solvent was removed by distillation under the reduced pressure. The residue was purified by column chromatography using chloroform-acetone to give 7-benzyloxy-4-(2-iodo-6-methyl-pyridin-3-yloxy)-6-methoxy-quinoline (5.2 g, yield 31%).

1. customto prepare a solution
2. temperatureThe reaction solution was cooled to room temperature
3. customthe solvent was then removed by distillation under the reduced pressure
4. additionWater was added to the residue
5. extractionthe mixture was extracted with chloroform
6. washthe chloroform layer was then washed with water
7. dry with materialwas dried over anhydrous sodium sulfate
8. customThe solvent was removed by distillation under the reduced pressure
9. customThe residue was purified by column chromatography