Aluminium lithium hydride → HCID 70269844, compound

HRID 2289374Notes

Reaction equation

HRID 2289374 reaction equation
[H-].[Al+3].[Li+].[H-].[H-].[H-].[O:7]1[CH2:12][CH2:11][CH2:10][CH2:9][CH:8]1[O:13][C@H:14]([CH2:19][C@@H:20]([CH3:25])[CH2:21][CH2:22][CH2:23][CH3:24])[C:15](OC)=[O:16]>C(OCC)C>[O:7]1[CH2:12][CH2:11][CH2:10][CH2:9][CH:8]1[O:13][C@H:14]([CH2:19][C@@H:20]([CH3:25])[CH2:21][CH2:22][CH2:23][CH3:24])[CH2:15][OH:16]

Participants

4

Reactant 2

HCID 21226445Aluminium lithium hydrideHCID 57194080HCID 57194080, compound

Product 1

HCID 70269844HCID 70269844, compoundYield 79.4%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent2×

Procedure

A mixture of 0.6 g of lithium aluminum hydride and 60 ml of diethyl ether was kept at -5° to -10° C., and a solution of the ester derivative (2.12 g) obtained in Step 8 in 50 ml of diethyl ether was added thereto dropwise, followed by stirring at that temperature for 2 hours. The reaction mixture was poured into ice-water and extracted with diethyl ether. The extract was washed with water and distilled to remove the solvent to obtain 1.51 g (70.01%) of the titled compound.

Workup

  1. customwas kept at -5° to -10° C.
  2. extractionextracted with diethyl ether
  3. washThe extract was washed with water
  4. distillationdistilled
  5. customto remove the solvent

Sources & evidence

ORD record
ord-fdff06a865294a099263701908c9b0bf
Source dataset
uspto-grants-2000_07
Patent number
US06093345

Reaction notes

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