Sulfuric Acid → HCID 10953530, compound

HRID 2289384Notes

Reaction equation

HRID 2289384 reaction equation
[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][CH3:6].S(=O)(=O)(O)O.C([O:14][CH2:15][CH3:16])C>>[CH3:1][C@H:2]([CH2:3][CH2:4][CH2:5][CH3:6])[CH2:16][CH:15]=[O:14]

Participants

4

Reactant 3

HCID 1118Sulfuric AcidHCID 3283Diethyl EtherHCID 8058Hexane

Product 1

HCID 10953530HCID 10953530, compoundYield 86.2%

Conditions

Temperature
0 °C

Procedure

In a 300 ml flask were charged 86 ml of hexane and 56 g of (R)-3-methyl-1-heptenyldiethylamine obtained in Step 1, followed by cooling to 0° C. To the solution was added 73 g of 20% sulfuric acid over 1.5 hours, followed by stirring for 20 minutes. After completion of the reaction, 50 ml of diethyl ether was added thereto, and the reaction mixture was washed with water. The solvent was removed by distillation to obtain 34.2 g (86.2%) of a crude product.

Workup

  1. additionwas added
  2. washthe reaction mixture was washed with water
  3. customThe solvent was removed by distillation

Sources & evidence

ORD record
ord-9f0d12f11f9d4e0eb401329ddc0437df
Source dataset
uspto-grants-2000_07
Patent number
US06093345

Reaction notes

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