Sulfuric Acid → HCID 10953530, compound

Participants

Reaction Conditions

Reaction Steps

In a 300 ml flask were charged 86 ml of hexane and 56 g of (R)-3-methyl-1-heptenyldiethylamine obtained in Step 1, followed by cooling to 0° C. To the solution was added 73 g of 20% sulfuric acid over 1.5 hours, followed by stirring for 20 minutes. After completion of the reaction, 50 ml of diethyl ether was added thereto, and the reaction mixture was washed with water. The solvent was removed by distillation to obtain 34.2 g (86.2%) of a crude product.

Provenance & Evidence