反应详情

温度

150 °C

3-Hydroxy-2-methyl-4-quinoline carboxylic acid (1.5 g), 7-benzyloxy-4-chloro-6-methoxyquinoline (2 g), and 4-(N,N-dimethylamino)-pyridine (2.4 g) were dissolved in 1,2-dichlorobenzene (70 ml) to prepare a solution which was then stirred at 150° C. overnight. The reaction solution was cooled to room temperature, and the solvent was then removed by distillation under the reduced pressure. Water was added to the residue, and the mixture was extracted with chloroform and was dried over anhydrous sodium sulfate. The solvent was removed by distillation under the reduced pressure. The residue was purified by column chromatography using hexane-acetone to give the title compound (2.4 g, yield 85%).

1. customto prepare a solution which
2. temperatureThe reaction solution was cooled to room temperature
3. customthe solvent was then removed by distillation under the reduced pressure
4. additionWater was added to the residue
5. extractionthe mixture was extracted with chloroform
6. dry with materialwas dried over anhydrous sodium sulfate
7. customThe solvent was removed by distillation under the reduced pressure
8. customThe residue was purified by column chromatography