反应详情

2-{2-[6-Methoxy-4-(2-methyl-quinolin-3-yloxy)-quinolin-7-yloxy]-ethyl}-isoindole-1,3-dione (compound 367) (20 mg) was dissolved in N,N-dimethylformamide (2 ml) to prepare a solution, hydrazine (13 mg) was added to the solution, and the mixture was stirred at room temperature for 4 hr. The solvent was removed by distillation under the reduced pressure, and the residue was purified by thin layer chromatography using chloroform-methanol to give the title compound (16 mg, yield 98%).

1. additionwas added to the solution
2. customThe solvent was removed by distillation under the reduced pressure
3. customthe residue was purified by thin layer chromatography