反应详情

A solution of 4,6-dichloropyrimidine (10.05 g), tert-butoxycarbonylpiperazine (11.94 g) and triethylamine (28.20 ml) in ethanol (150 ml) was heated at reflux for 18 hours. Solvent was evaporated and the residue dissolved in ethyl acetate and washed with water, saturated aqueous ammonium chloride solution, dried (Na2SO4) and evaporated. Recrystallisation from ethyl acetate/hexane gave, as a solid 1-(tert-butoxycarbonyl)-4-(6-chloro-pyrimidin-4-yl)piperazine (16.80 g).

1. temperatureat reflux for 18 hours
2. customSolvent was evaporated
3. dissolutionthe residue dissolved in ethyl acetate
4. washwashed with water, saturated aqueous ammonium chloride solution
5. dry with materialdried (Na2SO4)
6. customevaporated
7. customRecrystallisation from ethyl acetate/hexane