HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4-Chloro-6-(piperazin-1-yl)pyrimidine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | tert-Butyl 4-(6-chloropyrimidin-4-yl)piperazine-1-carboxylate | HCID 18697980 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 4-Chloro-6-(piperazin-1-yl)pyrimidine hydrochloride | HCID 18697979 | 200.4% |
Reaction Steps
Ethyl acetate saturated with gaseous HCl was added to a solution of 1-(tert-butoxycarbonyl)-4-(6-chloro-pyrimidin-4-yl)piperazine (16.80 g) in ethyl acetate (50 ml) and the resulting suspension stirred at ambient temperature for 3 hours. Solvent was evaporated to give (6-chloro-pyrimidin-4-yl)piperazine hydrochloride (13.25 g) as a cream solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06093718 |
| Source dataset | uspto-grants-2000_07 |
| ORD ID | ord-43ece320d2f443b68284d114248a097a |
| Source note | uspto-grants-2000_07 |