HRID2289553

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID313

Hydrochloric Acid

ClH

HCID18697980

tert-Butyl 4-(6-chloropyrimidin-4-yl)piperazine-1-carboxylate

C13H19ClN4O2

PRODUCTS

生成物

HCID18697979

4-Chloro-6-(piperazin-1-yl)pyrimidine--hydrogen chloride (1/1)

C8H12Cl2N4

收率 200.4%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID8857

Ethyl acetate

C4H8O2

2 次

PROCEDURE

实验过程

Ethyl acetate saturated with gaseous HCl was added to a solution of 1-(tert-butoxycarbonyl)-4-(6-chloro-pyrimidin-4-yl)piperazine (16.80 g) in ethyl acetate (50 ml) and the resulting suspension stirred at ambient temperature for 3 hours. Solvent was evaporated to give (6-chloro-pyrimidin-4-yl)piperazine hydrochloride (13.25 g) as a cream solid.

WORKUP

后处理

customSolvent was evaporated