HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 18698053, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 1,1-Dimethylethyl 4-[[1-(6-methyl-4-pyrimidinyl)-4-piperidinyl]carbonyl]-1-piperazinecarboxylate | HCID 18698029 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 18698053 | HCID 18698053 | — |
Reaction Steps
Ethyl acetate saturated with gaseous HCl was added to a solution of 1-(tert-butoxycarbonyl)-4-[1-(6-methylpyrimidin-4-yl)-4-piperidylcarbonyl] piperazine (14.07 g) in ethyl acetate (50 ml) and the resulting suspension stirred at ambient temperature for 3 hours. Solvent was evaporated to give 4-[1-(6-methylpyrimidin-4-yl)-4-piperidylcarbonyl] piperazine hydrochloride (11.79 g) as a solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06093718 |
| Source dataset | uspto-grants-2000_07 |
| ORD ID | ord-d0e5305a070642caa1e564a3e7ccb64a |
| Source note | uspto-grants-2000_07 |