Hydrochloric Acid → HCID 18698053, compound

HRID 2289556Notes

Reaction equation

HRID 2289556 reaction equation
[ClH:1].C(OC([N:9]1[CH2:14][CH2:13][N:12]([C:15]([CH:17]2[CH2:22][CH2:21][N:20]([C:23]3[CH:28]=[C:27]([CH3:29])[N:26]=[CH:25][N:24]=3)[CH2:19][CH2:18]2)=[O:16])[CH2:11][CH2:10]1)=O)(C)(C)C>C(OCC)(=O)C>[ClH:1].[CH3:29][C:27]1[N:26]=[CH:25][N:24]=[C:23]([N:20]2[CH2:21][CH2:22][CH:17]([C:15]([N:12]3[CH2:13][CH2:14][NH:9][CH2:10][CH2:11]3)=[O:16])[CH2:18][CH2:19]2)[CH:28]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 186980291,1-Dimethylethyl 4-[[1-(6-methyl-4-pyrimidinyl)-4-piperidinyl]carbonyl]-1-piperazinecarboxylate

Product 1

HCID 18698053HCID 18698053, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Procedure

Ethyl acetate saturated with gaseous HCl was added to a solution of 1-(tert-butoxycarbonyl)-4-[1-(6-methylpyrimidin-4-yl)-4-piperidylcarbonyl] piperazine (14.07 g) in ethyl acetate (50 ml) and the resulting suspension stirred at ambient temperature for 3 hours. Solvent was evaporated to give 4-[1-(6-methylpyrimidin-4-yl)-4-piperidylcarbonyl] piperazine hydrochloride (11.79 g) as a solid.

Workup

  1. customSolvent was evaporated

Sources & evidence

ORD record
ord-d0e5305a070642caa1e564a3e7ccb64a
Source dataset
uspto-grants-2000_07
Patent number
US06093718

Reaction notes

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