2-Bromopyridine → HCID 18698769, compound

HRID 2289623Notes

Reaction equation

HRID 2289623 reaction equation
[ClH:1].[O:2]=[C:3]1[CH:8]=[C:7]([CH2:9][N:10]2[C:14]([CH2:15][C:16]3[CH:23]=[CH:22][C:19]([C:20]#[N:21])=[CH:18][CH:17]=3)=[CH:13][N:12]=[CH:11]2)[CH:6]=[CH:5][N:4]1[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26]C=1.BrC1C=CC=C[N:32]=1.IC1C=CC=CC=1>>[ClH:1].[O:2]=[C:3]1[CH:8]=[C:7]([CH2:9][N:10]2[C:14]([CH2:15][C:16]3[CH:23]=[CH:22][C:19]([C:20]#[N:21])=[CH:18][CH:17]=3)=[CH:13][N:12]=[CH:11]2)[CH:6]=[CH:5][N:4]1[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][N:32]=1

Participants

4

Reactant 3

HCID 79732-BromopyridineHCID 11575IodobenzeneHCID 131721912HCID 131721912, compound

Product 1

HCID 18698769HCID 18698769, compound

Procedure

4-[3-(2-Oxo-2H-[1,2']bipyridinyl-4-ylmethyl)-3H-imidazol-4-ylmethyl]-benzonitrile hydrochloride salt was prepared in a manner substantially similar to the procedure described above for 4-[3-(2-oxo-1-phenyl-1,2-dihydropyridin-4-ylmethyl)-3H-imidazol-4-ylmethyl]benzonitrile, hydrochloride, but substituting 2-bromopyridine for the iodobenzene in Step 3.

Sources & evidence

ORD record
ord-580faeb2613e45a0a5e03101fdff7863
Source dataset
uspto-grants-2000_07
Patent number
US06093737

Reaction notes

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