Hydrochloride methanol → HCID 23078411, compound

HRID 228967Notes

Reaction equation

HRID 228967 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH2:14][CH2:15][N:16]1[CH2:21][CH2:20][O:19][CH2:18][CH2:17]1)[N:9]=[CH:8][CH:7]=[C:6]2[O:22][C:23]1[C:24]([CH3:33])=[N:25][C:26]2[C:31]([CH:32]=1)=[CH:30][CH:29]=[CH:28][CH:27]=2.[ClH:34].CO>>[ClH:34].[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH2:14][CH2:15][N:16]1[CH2:17][CH2:18][O:19][CH2:20][CH2:21]1)[N:9]=[CH:8][CH:7]=[C:6]2[O:22][C:23]1[C:24]([CH3:33])=[N:25][C:26]2[C:31]([CH:32]=1)=[CH:30][CH:29]=[CH:28][CH:27]=2

Participants

3

Reactant 2

HCID 21893726Hydrochloride methanolHCID 23078262HCID 23078262, compound2×

Product 1

HCID 23078411HCID 23078411, compoundYield 59%

Procedure

A hydrochloric acid/methanol solution (30 ml) was added to 6-methoxy-4-(2-methyl-quinolin-3-yloxy)-7-(2-morpholin-4-yl-ethoxy)-quinoline (compound 365) (748 mg), and the mixture was stirred at room temperature for one hr. The solvent was removed by distillation under the reduced pressure to give the title compound (900 mg, yield 59%).

Workup

  1. customThe solvent was removed by distillation under the reduced pressure

Sources & evidence

ORD record
ord-a61a77b601f241fe85d7f156fbfaa5c4
Source dataset
uspto-grants-2009_07
Patent number
US07560558B2

Reaction notes

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