Trifluoroacetic acid → HCID 178512670, compound

HRID 2289703Notes

Reaction equation

HRID 2289703 reaction equation
Cl.C([O:6][C:7](=[O:28])[CH2:8][NH:9][S:10]([C:13]1[CH:22]=[C:21]2[C:16]([C:17]([Cl:27])=[CH:18][N:19]=[C:20]2[NH:23][C:24]([NH2:26])=[NH:25])=[CH:15][CH:14]=1)(=[O:12])=[O:11])(C)(C)C.[C:29]([C:33]([OH:35])=[O:34])([F:32])([F:31])[F:30]>C1(C)C=CC=CC=1>[F:30][C:29]([F:32])([F:31])[C:33]([OH:35])=[O:34].[Cl:27][C:17]1[C:16]2[C:21](=[CH:22][C:13]([S:10]([NH:9][CH2:8][C:7]([OH:28])=[O:6])(=[O:11])=[O:12])=[CH:14][CH:15]=2)[C:20]([NH:23][C:24]([NH2:26])=[NH:25])=[N:19][CH:18]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 178451317HCID 178451317, compound

Product 1

HCID 178512670HCID 178512670, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

N-[(4-Chloro-1-guanidino-7-isoquinolinyl)sulphonyl]glycine t-butyl ester hydrochloride (50 mg, 0.11 mmol) was dissolved in CF3CO2H (1.0 mL) and the mixture stirred at room temperature for 1.5 h. The mixture was diluted with PhMe and the solvents were evaporated in vacuo. The residue was triturated with Et2O and EtOAc to give N-[(4-chloro-1-guanidino-7-isoquinolinyl)sulphonyl]glycine trifluoroacetate (36 mg, 0.073 mmol) as a white powder.

Workup

  1. customthe solvents were evaporated in vacuo
  2. customThe residue was triturated with Et2O and EtOAc

Sources & evidence

ORD record
ord-bf2c626f1ee740918672543305429a93
Source dataset
uspto-grants-2000_07
Patent number
US06093731

Reaction notes

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