Trifluoroacetic acid → HCID 178484756, compound

HRID 2289707Notes

Reaction equation

HRID 2289707 reaction equation
C([O:5][C:6](=[O:28])[CH2:7][N:8]([S:10]([C:13]1[CH:22]=[C:21]2[C:16]([C:17]([Cl:27])=[CH:18][N:19]=[C:20]2[NH:23][C:24]([NH2:26])=[NH:25])=[CH:15][CH:14]=1)(=[O:12])=[O:11])[CH3:9])(C)(C)C.[C:29]([C:33]([OH:35])=[O:34])([F:32])([F:31])[F:30]>C(Cl)Cl.C1(C)C=CC=CC=1>[F:30][C:29]([F:32])([F:31])[C:33]([OH:35])=[O:34].[F:30][C:29]([F:32])([F:31])[C:33]([OH:35])=[O:34].[Cl:27][C:17]1[C:16]2[C:21](=[CH:22][C:13]([S:10]([N:8]([CH3:9])[CH2:7][C:6]([OH:28])=[O:5])(=[O:11])=[O:12])=[CH:14][CH:15]=2)[C:20]([NH:23][C:24]([NH2:26])=[NH:25])=[N:19][CH:18]=1

Participants

5

Reactant 2

HCID 6422Trifluoroacetic acidHCID 178484747HCID 178484747, compound

Product 1

HCID 178484756HCID 178484756, compound

Reagents, catalysts & solvents 2

HCID 1140TolueneSolventHCID 6344DichloromethaneSolvent

Procedure

N-[(4-Chloro-1-guanidino-7-isoquinolinyl)sulphonyl]-N-methylglycine t-butyl ester (255 mg, 5.96 mmol) was dissolved in CF3CO2H (4.0 mL) and CH2Cl2 (2.0 mL), and the mixture stirred at room temperature for 1 h. The mixture was diluted with PhMe and the solvents were evaporated in vacuo to give N-[(4-chloro-1-guanidino-7-isoquinolinyl)sulphonyl]-N-methylglycine bis(trifluoroacetate) (349 mg, 0.56 mmol) as a white powder.

Workup

  1. customthe solvents were evaporated in vacuo

Sources & evidence

ORD record
ord-795142f4195b4a719ed2ce7d2c4d92a0
Source dataset
uspto-grants-2000_07
Patent number
US06093731

Reaction notes

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