Dichloromethane → HCID 178512671, compound

HRID 2289713Notes

Reaction equation

HRID 2289713 reaction equation
C([O:5][C:6](=[O:34])[CH2:7][N:8]([S:16]([C:19]1[CH:28]=[C:27]2[C:22]([C:23]([Cl:33])=[CH:24][N:25]=[C:26]2[NH:29][C:30]([NH2:32])=[NH:31])=[CH:21][CH:20]=1)(=[O:18])=[O:17])[CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)(C)(C)C.C(Cl)Cl.[C:38]([C:42]([OH:44])=[O:43])([F:41])([F:40])[F:39]>C1(C)C=CC=CC=1>[F:39][C:38]([F:41])([F:40])[C:42]([OH:44])=[O:43].[Cl:33][C:23]1[C:22]2[C:27](=[CH:28][C:19]([S:16]([N:8]([CH2:9][C:10]3[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=3)[CH2:7][C:6]([OH:34])=[O:5])(=[O:17])=[O:18])=[CH:20][CH:21]=2)[C:26]([NH:29][C:30]([NH2:32])=[NH:31])=[N:25][CH:24]=1

Participants

5

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 178451235HCID 178451235, compound

Product 1

HCID 178512671HCID 178512671, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

N-[(4-Chloro-1-guanidino-7-isoquinolinyl)sulphonyl]-N-benzylglycine t-butyl ester (50 mg, 0.10 mmol) was dissolved in CF3CO2H (1.0 mL) and the mixture stirred at room temperature for 1 h. The mixture was diluted with PhMe and the solvents were evaporated in vacuo. The residue was azeotroped with PhMe and then CH2Cl2 to give N-[(4-chloro-1-guanidino-7-isoquinolinyl)sulphonyl]-N-benzylglycine trifluoroacetate (52 mg, 0.10 mmol) as a white solid.

Workup

  1. customthe solvents were evaporated in vacuo
  2. customThe residue was azeotroped with PhMe

Sources & evidence

ORD record
ord-15be4744ab554987818e93c6ad8d87d0
Source dataset
uspto-grants-2000_07
Patent number
US06093731

Reaction notes

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