Trifluoroacetic acid → HCID 178512666, compound

HRID 2289751Notes

Reaction equation

HRID 2289751 reaction equation
[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([S:12]([NH:15][C:16]3([C:21]([OH:23])=[O:22])[CH2:20][CH2:19][CH2:18][CH2:17]3)(=[O:14])=[O:13])=[CH:9][CH:10]=2)[C:5]([NH:24][C:25]([NH2:27])=[NH:26])=[N:4][CH:3]=1.[C:28]([C:32]([OH:34])=[O:33])([F:31])([F:30])[F:29]>CO>[F:29][C:28]([F:31])([F:30])[C:32]([OH:34])=[O:33].[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([S:12]([NH:15][C:16]3([C:21]([OH:23])=[O:22])[CH2:20][CH2:19][CH2:18][CH2:17]3)(=[O:13])=[O:14])=[CH:9][CH:10]=2)[C:5]([NH:24][C:25]([NH2:27])=[NH:26])=[N:4][CH:3]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 178512665HCID 178512665, compound

Product 1

HCID 178512666HCID 178512666, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

N-[(4-Chloro-1-guanidino-7-isoquinolinyl)sulphonyl]cycloleucine (8 mg) was dissolved in CF3CO2H (ca. 1.0 mL) and the mixture was evaporated in vacuo, azeotroping with PhMe. The residue was triturated with i-Pr2O and Et2O to give a white solid. The solid was dissolved in MeOH, filtered and the filtrate evaporated in vacuo to give N-[(4-chloro-1-guanidino-7-isoquinolinyl)sulphonyl]cycloleucine trifluoroacetate (12 mg).

Workup

  1. customthe mixture was evaporated in vacuo
  2. customazeotroping with PhMe
  3. customThe residue was triturated with i-Pr2O and Et2O
  4. customto give a white solid
  5. filtrationfiltered
  6. customthe filtrate evaporated in vacuo

Sources & evidence

ORD record
ord-d82315701c814879aa62e53703f61f7b
Source dataset
uspto-grants-2000_07
Patent number
US06093731

Reaction notes

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