Trifluoroacetic acid → HCID 178512647, compound

HRID 2289770Notes

Reaction equation

HRID 2289770 reaction equation
C([O:5][C:6](=[O:29])[CH:7]1[CH2:11][CH2:10][CH2:9][N:8]1[C:12]([C:14]1[CH:23]=[C:22]2[C:17]([C:18]([Cl:28])=[CH:19][N:20]=[C:21]2[NH:24][C:25]([NH2:27])=[NH:26])=[CH:16][CH:15]=1)=[O:13])(C)(C)C.[C:30]([C:34]([OH:36])=[O:35])([F:33])([F:32])[F:31]>C1(C)C=CC=CC=1>[F:31][C:30]([F:33])([F:32])[C:34]([OH:36])=[O:35].[Cl:28][C:18]1[C:17]2[C:22](=[CH:23][C:14]([C:12]([N:8]3[CH2:9][CH2:10][CH2:11][CH:7]3[C:6]([OH:29])=[O:5])=[O:13])=[CH:15][CH:16]=2)[C:21]([NH:24][C:25]([NH2:27])=[NH:26])=[N:20][CH:19]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 178450718HCID 178450718, compound

Product 1

HCID 178512647HCID 178512647, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A solution of N-[(4-Chloro-1-guanidino-7-isoquinolinyl)carbonyl]-DL-proline t-butyl ester (175 mg, 0.42 mmol) in CF3CO2H (1 mL) was stirred at room temperature for 1 h. The solution was diluted with PhMe, evaporated in vacuo, and the residue was triturated with Et2O to give N-[(4-chloro-1-guanidino-7-isoquinolinyl)carbonyl]-DL-proline trifluoroacetate (156 mg, 0.33 mmol) as a white solid.

Workup

  1. customevaporated in vacuo
  2. customthe residue was triturated with Et2O

Sources & evidence

ORD record
ord-0aedaec0b49e490c88e5ae694826b447
Source dataset
uspto-grants-2000_07
Patent number
US06093731

Reaction notes

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