Trifluoroacetic acid → HCID 178512649, compound

HRID 2289772Notes

Reaction equation

HRID 2289772 reaction equation
C([O:5][C:6](=[O:33])[CH:7]([CH2:26][C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1)[NH:8][C:9]([C:11]1[CH:20]=[C:19]2[C:14]([C:15]([Cl:25])=[CH:16][N:17]=[C:18]2[NH:21][C:22]([NH2:24])=[NH:23])=[CH:13][CH:12]=1)=[O:10])(C)(C)C.[C:34]([C:38]([OH:40])=[O:39])([F:37])([F:36])[F:35]>C1(C)C=CC=CC=1>[F:35][C:34]([F:37])([F:36])[C:38]([OH:40])=[O:39].[Cl:25][C:15]1[C:14]2[C:19](=[CH:20][C:11]([C:9]([NH:8][CH:7]([C:6]([OH:33])=[O:5])[CH2:26][C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=3)=[O:10])=[CH:12][CH:13]=2)[C:18]([NH:21][C:22]([NH2:24])=[NH:23])=[N:17][CH:16]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 178450909HCID 178450909, compound

Product 1

HCID 178512649HCID 178512649, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A solution of N-[(4-Chloro-1-guanidino-7-isoquinolinyl)carbonyl]-DL-phenylalanine t-butyl ester (210 mg, 0.48 mmol) in CF3CO2H (1 mL) was stirred at room temperature for 1 h. The solution was diluted with PhMe, evaporated in vacuo, and the residue was triturated with Et2O to give N-[(4-chloro-1-guanidino-7-isoquinolinyl)carbonyl]-DL-phenylalanine trifluoroacetate (196 mg, 0.37 mmol).

Workup

  1. customevaporated in vacuo
  2. customthe residue was triturated with Et2O

Sources & evidence

ORD record
ord-08c4e0d848754d509ce140cdbef99160
Source dataset
uspto-grants-2000_07
Patent number
US06093731

Reaction notes

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