Trifluoroacetic acid → HCID 178446465, compound

HRID 2289773Notes

Reaction equation

HRID 2289773 reaction equation
C([O:5][C:6](=[O:30])[CH:7]([CH2:26][CH:27]([CH3:29])[CH3:28])[NH:8][C:9]([C:11]1[CH:20]=[C:19]2[C:14]([C:15]([Cl:25])=[CH:16][N:17]=[C:18]2[NH:21][C:22]([NH2:24])=[NH:23])=[CH:13][CH:12]=1)=[O:10])(C)(C)C.[C:31]([C:35]([OH:37])=[O:36])([F:34])([F:33])[F:32]>C1(C)C=CC=CC=1>[F:32][C:31]([F:34])([F:33])[C:35]([OH:37])=[O:36].[Cl:25][C:15]1[C:14]2[C:19](=[CH:20][C:11]([C:9]([NH:8][CH:7]([C:6]([OH:30])=[O:5])[CH2:26][CH:27]([CH3:29])[CH3:28])=[O:10])=[CH:12][CH:13]=2)[C:18]([NH:21][C:22]([NH2:24])=[NH:23])=[N:17][CH:16]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 178446464HCID 178446464, compound

Product 1

HCID 178446465HCID 178446465, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A solution of N-[(4-chloro-1-guanidino-7-isoquinolinyl)carbonyl]-DL-leucine t-butyl ester (184 mg, 0.57 mmol) in CF3CO2H (1 mL) was stirred at room temperature for 1 h. The solution was diluted with PhMe, evaporated in vacuo, and the residue was triturated with Et2O to give N-[(4-chloro-1-guanidino-7-isoquinolinyl)carbonyl]-DL-leucine trifluoroacetate (183 mg, 0.37 mmol).

Workup

  1. customevaporated in vacuo
  2. customthe residue was triturated with Et2O

Sources & evidence

ORD record
ord-a123b208ad974aae8b5e285addb93f6e
Source dataset
uspto-grants-2000_07
Patent number
US06093731

Reaction notes

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