Trifluoroacetic acid → HCID 178512651, compound

HRID 2289774Notes

Reaction equation

HRID 2289774 reaction equation
[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([C:12]([NH:14][CH:15]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)[CH2:16][C:17]([O-:19])=[O:18])=[O:13])=[CH:9][CH:10]=2)[C:5]([NH:26][C:27]([NH2:29])=[NH:28])=[N:4][CH:3]=1.[C:30]([C:34]([OH:36])=[O:35])([F:33])([F:32])[F:31]>C1(C)C=CC=CC=1>[F:31][C:30]([F:33])([F:32])[C:34]([OH:36])=[O:35].[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([C:12]([NH:14][CH:15]([C:20]3[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=3)[CH2:16][C:17]([OH:19])=[O:18])=[O:13])=[CH:9][CH:10]=2)[C:5]([NH:26][C:27]([NH2:29])=[NH:28])=[N:4][CH:3]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 178512650HCID 178512650, compound

Product 1

HCID 178512651HCID 178512651, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A solution of t-butyl DL-3-{[(4-chloro-1-guanidino-7-isoquinolinyl)carbonyl]amino}-3-phenylpropanoate (153 mg, 0.33 mmol) in CF3CO2H (1 mL) was stirred at room temperature for 1 h. The solution was diluted with PhMe, evaporated in vacuo, and the residue was triturated with Et2O to give DL-3-{[(4-chloro-1-guanidino-7-isoquinolinyl)carbonyl]amino}-3-phenylpropanoic acid trifluoroacetate (132 mg, 0.25 mmol).

Workup

  1. customevaporated in vacuo
  2. customthe residue was triturated with Et2O

Sources & evidence

ORD record
ord-8e8ddf89b20f4ae3bc9405c246c6f139
Source dataset
uspto-grants-2000_07
Patent number
US06093731

Reaction notes

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