Methyl 1-(3-(hydroxymethyl)phenyl)-5-oxopyrrolidine-3-carboxylate → HCID 131724724, compound

HRID 22898Notes

Reaction equation

HRID 22898 reaction equation
[OH:1][CH2:2][C:3]1[CH:4]=[C:5]([N:9]2[C:13](=[O:14])[CH2:12][CH:11]([C:15]([O:17][CH3:18])=[O:16])[CH2:10]2)[CH:6]=[CH:7][CH:8]=1.[Cr](Cl)([O-])(=O)=O.[NH+]1C=CC=CC=1>C(Cl)Cl>[CH:2]([C:3]1[CH:4]=[C:5]([N:9]2[C:13](=[O:14])[CH2:12][CH:11]([C:15]([O:17][CH3:18])=[O:16])[CH2:10]2)[CH:6]=[CH:7][CH:8]=1)=[O:1]

Participants

4

Reactant 2

HCID 22591870Methyl 1-(3-(hydroxymethyl)phenyl)-5-oxopyrrolidine-3-carboxylateHCID 178418287HCID 178418287, compound

Product 1

HCID 131724724HCID 131724724, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of methyl 1-(3-(hydroxymethyl)phenyl)-5-oxopyrrolidine-3-carboxylate in CH2Cl2 was added pyridinium chlorochromate (PCC). The reaction was stirred at room temperature overnight. The mixture was then filtered through a pad of celite. The filtrate was concentrated in vacuo and the desired product was obtained after silica gel chromatograph. MS (ES+): 248.0 (M+H)+.

Workup

  1. filtrationThe mixture was then filtered through a pad of celite
  2. concentrationThe filtrate was concentrated in vacuo

Sources & evidence

ORD record
ord-c1b050261f1c457e9455ca6df6938a6d
Source dataset
uspto-grants-2005_02
Patent number
US06849639B2

Reaction notes

Loading…