反应详情

1,4-Dichloro-7-isoquinolinesulphonyl chloride ##STR107## A solution of N-chlorosuccinimide (9.66 g, 72 mmol) in MeCN (80 mL) was added dropwise to a stirred solution of 1-(2H)-isoquinolone (10 g, 69 mmol) in MeCN (250 mL) which was being heated under reflux. The mixture was heated under reflux for an additional 1.5 h and then cooled to room temperature. The resulting precipitate was collected by filtration, with MeCN rinsing, and then dried in vacuo to give 4-chloro-1(2H)-isoquinolone (11.3 g, 62.9 mmol) as a pale pink solid.

1. temperaturewas being heated
2. temperatureunder reflux
3. temperatureThe mixture was heated
4. temperatureunder reflux for an additional 1.5 h
5. filtrationThe resulting precipitate was collected by filtration, with MeCN rinsing
6. customdried in vacuo