HCID 18698966, compound → HCID 18698957, compound

HRID 2289834Notes

Reaction equation

HRID 2289834 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]([C:20]2[CH:25]=[CH:24][C:23]([O:26][CH3:27])=[CH:22][CH:21]=2)([C:11]2[CH:16]=[CH:15][C:14]([N+:17]([O-])=O)=[CH:13][CH:12]=2)[CH3:10])=[CH:5][CH:4]=1.[H][H]>[C].[Pd].O1CCCC1>[CH3:27][O:26][C:23]1[CH:22]=[CH:21][C:20]([C:9]([C:6]2[CH:5]=[CH:4][C:3]([O:2][CH3:1])=[CH:8][CH:7]=2)([C:11]2[CH:16]=[CH:15][C:14]([NH2:17])=[CH:13][CH:12]=2)[CH3:10])=[CH:25][CH:24]=1

Participants

5

Reactant 2

HCID 18698966HCID 18698966, compound2×HCID 178418361HCID 178418361, compound

Product 1

HCID 18698957HCID 18698957, compound

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 8028TetrahydrofuranSolvent

Procedure

70 g (0.19 mol) of the above synthesized 1,1-bis(4-methoxyphenyl)-1-(4-nitro-phenyl)ethane, 200 ml of tetrahydrofuran and 3.5 g of palladium carbon were placed in an Erlenmeyer flask, and the 1,1-bis(4-methoxyphenyl)-1-(4-nitro-phenyl)ethane was reduced by 13.65 l of hydrogen. After this reduction reaction, the tetrahydrofuran was distilled away from the reaction mixture under reduced pressure, whereby 1,1-bis(4-methoxyphenyl)-1-(4-amino-phenyl)ethane was obtained in the form of a white solid in a yield of 64.2 g.

Workup

  1. customAfter this reduction reaction
  2. distillationthe tetrahydrofuran was distilled away from the reaction mixture under reduced pressure

Sources & evidence

ORD record
ord-1b719c2489b048cd9c004693d4530183
Source dataset
uspto-grants-2000_07
Patent number
US06093784

Reaction notes

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