Formamide → HCID 18374041, compound

HRID 2289876Notes

Reaction equation

[CH:1]([NH2:3])=[O:2].[Cl:4][C:5]1[CH:10]=[CH:9][C:8]([C:11](=O)[CH3:12])=[CH:7][CH:6]=1>>[CH:1]([NH:3][CH:11]([C:8]1[CH:9]=[CH:10][C:5]([Cl:4])=[CH:6][CH:7]=1)[CH3:12])=[O:2]

Participants

Reactant 2

HCID 713Formamide

HCID 7467P-Chloroacetophenone

Product 1

HCID 18374041HCID 18374041, compoundYield 99.7%

Procedure

In the same manner as in Example 1 except that 110.7 g of formamide was used in place of ammonium formate and 126.7 g of 4'-chloroacetophenone was used in place of acetophenone, the reaction and post treatment were carried out to obtain 150 g of crude N-formyl-1-(4-chlorophenyl)ethylamine; the purity: 87.4%.

Workup

customthe reaction and post treatment

Sources & evidence

ORD record: ord-04e904b8a2df40d0b1dfb64e01c512b5
Source dataset: uspto-grants-2000_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06093851

Reaction notes

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