Acetophenone → N-Formyl-1-phenylethylamine

HRID 2289878Notes

Reaction equation

HRID 2289878 reaction equation
[CH:1]([O-:3])=O.[NH4+:4].[C:5]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)(=O)[CH3:6]>C(O)=O>[CH:1]([NH:4][CH:5]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[CH3:6])=[O:3]

Participants

4

Reactant 2

HCID 7410Acetophenone2×HCID 2723923Ammonium formate2×

Product 1

HCID 97904N-Formyl-1-phenylethylamine

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent2×

Procedure

In the same manner as in Example 1 except that a mixture of formic acid, ammonium formate and acetophenone was heated with stirring at 160° C. for 6 hours in place of the concurrent addition of acetophenone and formic acid to ammonium formate for 3 hours and keeping the mass after the addition stirred for 3 hours, the reaction and post treatment were carried out to obtain 112 g of crude N-formyl-1-phenylethylamine; the purity: 82.7%.

Workup

  1. temperaturewas heated
  2. additionafter the addition
  3. customthe reaction and post treatment

Sources & evidence

ORD record
ord-8468a00c9f9943b183cfdddcc8e40cb4
Source dataset
uspto-grants-2000_07
Patent number
US06093851

Reaction notes

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