2',4'-Dichloroacetophenone → HCID 5138776, compound

HRID 2289879Notes

Reaction equation

HRID 2289879 reaction equation
[CH:1]([O-:3])=O.[NH4+:4].[Cl:5][C:6]1[CH:11]=[C:10]([Cl:12])[CH:9]=[CH:8][C:7]=1[C:13](=O)[CH3:14]>C(O)=O>[CH:1]([NH:4][CH:13]([C:7]1[CH:8]=[CH:9][C:10]([Cl:12])=[CH:11][C:6]=1[Cl:5])[CH3:14])=[O:3]

Participants

4

Reactant 2

HCID 166932',4'-Dichloroacetophenone2×HCID 2723923Ammonium formate2×

Product 1

HCID 5138776HCID 5138776, compound

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent2×

Procedure

In the same manner as in Example 4 except that a mixture of formic acid, ammonium formate and 2',4'-dichloroacetophenone was heated with stirring at 160° C. for 6 hours in place of the concurrent addition of 2',4'-dichloroacetophenone and formic acid to ammonium formate for 3 hours and keeping the mass ater the addition stirred for 3 hours, the-reaction and post treatment were carried out to obtain 178.6 g of crude N-formyl-1-(2,4-dichlorophenyl)ethylamine; the purity: 70.4%.

Workup

  1. temperaturewas heated
  2. additionater the addition
  3. customthe-reaction and post treatment

Sources & evidence

ORD record
ord-9e766df306d84c94a94aace6cbfed429
Source dataset
uspto-grants-2000_07
Patent number
US06093851

Reaction notes

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