反应详情

Sodium cyanoborohydride (96 mg) is added to a mixture of 100 mg 7-amino-N-[(4-chlorophenyl)methyl]-4-hydroxy-3-quinolinecarboxamide and 91 mg paraformaldehyde in 5 mL of acetic acid. After 2 days the mixture is diluted with 5 mL of distilled water (use of more water causes the product to precipitate as an oil). The mixture is stirred an additional 10 min and then the product is collected by filtration. It is washed with three 1 mL portions of 50% aqueous acetic acid and dried in a stream of air. It is dried at 20 torr/24 h/75° C. The product is obtained as mg of an off-white powder.

1. customto precipitate as an oil)
2. filtrationthe product is collected by filtration
3. washIt is washed with three 1 mL portions of 50% aqueous acetic acid
4. customdried in a stream of air
5. customIt is dried at 20 torr/24 h/75° C
6. customThe product is obtained as mg of an off-white powder