HCID 178503675, compound → HCID 178503674, compound

HRID 2289984Notes

Reaction equation

HRID 2289984 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][NH:9][C:10]([C:12]2[CH:13]=[N:14][C:15]3[C:20]([C:21]=2[OH:22])=[CH:19][C:18]([C:23]#[C:24][CH2:25][S:26][CH3:27])=[CH:17][C:16]=3[F:28])=[O:11])=[CH:4][CH:3]=1>[Pd].C(Cl)Cl.CO>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:8][NH:9][C:10]([C:12]2[CH:13]=[N:14][C:15]3[C:20]([C:21]=2[OH:22])=[CH:19][C:18](/[CH:23]=[CH:24]\[CH2:25][S:26][CH3:27])=[CH:17][C:16]=3[F:28])=[O:11])=[CH:6][CH:7]=1

Participants

4

Reactant 1

HCID 178503675HCID 178503675, compound

Product 1

HCID 178503674HCID 178503674, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalyst2×HCID 21226129Dichloromethane methanolSolvent

Procedure

A mixture of N-[(4-Chlorophenyl)methyl]-8-fluoro-4-hydroxy-6-[3-(methylthio)-1-propynyl]-3-quinolinecarboxamide from Example 126 (0.226 g) and Pd/C (10%, 0.032 g) in 3:1 CH2Cl2 /MeOH (20 mL) are placed on a Parr hydrogenator under 38 psi of H2 and shaken for 2 h. Another 0.060 g of Pd/C is added, and the resulting

Sources & evidence

ORD record
ord-c4e04e7012964c3e955644fa744b539a
Source dataset
uspto-grants-2000_07
Patent number
US06093732

Reaction notes

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