HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 178503675, compound → HCID 178503674, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 178503675 | HCID 178503675 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Dichloromethane methanol | HCID 21226129 | — |
| Product | HCID 178503674 | HCID 178503674 | — |
Reaction Steps
A mixture of N-[(4-Chlorophenyl)methyl]-8-fluoro-4-hydroxy-6-[3-(methylthio)-1-propynyl]-3-quinolinecarboxamide from Example 126 (0.226 g) and Pd/C (10%, 0.032 g) in 3:1 CH2Cl2 /MeOH (20 mL) are placed on a Parr hydrogenator under 38 psi of H2 and shaken for 2 h. Another 0.060 g of Pd/C is added, and the resulting
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06093732 |
| Source dataset | uspto-grants-2000_07 |
| ORD ID | ord-c4e04e7012964c3e955644fa744b539a |
| Source note | uspto-grants-2000_07 |