Sodium Hydroxide → HCID 22591761, compound

HRID 22900Notes

Reaction equation

HRID 22900 reaction equation
[O:1]=[C:2]1[N:6]([C:7]2[CH:12]=[CH:11][CH:10]=[C:9]([CH2:13][NH:14][C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][N:16]=3)[CH:8]=2)[CH2:5][CH:4]([C:21]([O:23]C)=[O:22])[CH2:3]1.[OH-].[Na+].[OH-].[Na+].O.C1COCC1.CO>O.C1COCC1.CO>[O:1]=[C:2]1[N:6]([C:7]2[CH:12]=[CH:11][CH:10]=[C:9]([CH2:13][NH:14][C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][N:16]=3)[CH:8]=2)[CH2:5][CH:4]([C:21]([OH:23])=[O:22])[CH2:3]1

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 22591830HCID 22591830, compoundHCID 86584346NaOH water THF MeOH

Product 1

HCID 22591761HCID 22591761, compound

Reagents, catalysts & solvents 1

HCID 21892291Methanol tetrahydrofuran waterSolvent

Procedure

To a solution of methyl 5-oxo-1-{3-((2-pyridylamino)methyl)phenyl}pyrrolidine-3-carboxylate in water/THF/MeOH was added 1.0 eq 1N NaOH. The volume ratio of NaOH/water/THF/MeOH was 1:3:4:4. The reaction was stirred at room temperature overnight, and then concentrated in vacuo. The compound was used in the next step without further purification.

Workup

  1. concentrationconcentrated in vacuo
  2. customThe compound was used in the next step without further purification

Sources & evidence

ORD record
ord-b8c8c4831cee469d8d34ab9f9ec96606
Source dataset
uspto-grants-2005_02
Patent number
US06849639B2

Reaction notes

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