HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → HCID 22591761, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | HCID 22591830 | HCID 22591830 | — |
| Reactant | NaOH water THF MeOH | HCID 86584346 | — |
| Solvent | Methanol tetrahydrofuran water | HCID 21892291 | — |
| Product | HCID 22591761 | HCID 22591761 | — |
Reaction Steps
To a solution of methyl 5-oxo-1-{3-((2-pyridylamino)methyl)phenyl}pyrrolidine-3-carboxylate in water/THF/MeOH was added 1.0 eq 1N NaOH. The volume ratio of NaOH/water/THF/MeOH was 1:3:4:4. The reaction was stirred at room temperature overnight, and then concentrated in vacuo. The compound was used in the next step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06849639B2 |
| Source dataset | uspto-grants-2005_02 |
| ORD ID | ord-b8c8c4831cee469d8d34ab9f9ec96606 |
| Source note | uspto-grants-2005_02 |