Methyl 2',5'-dimethoxy-4-nitro-2-biphenylcarboxylate → 2',5'-Dimethoxy-4-nitro-2-biphenylcarboxylic acid

HRID 2290074Notes

Reaction equation

HRID 2290074 reaction equation
FC1C=CC(OC)=C(C2C(C(O)=O)=CC([N+]([O-])=O)=CC=2)C=1.[CH3:22][O:23][C:24]1[CH:29]=[CH:28][C:27]([O:30][CH3:31])=[CH:26][C:25]=1[C:32]1[C:33]([C:41]([O:43]C)=[O:42])=[CH:34][C:35]([N+:38]([O-:40])=[O:39])=[CH:36][CH:37]=1>>[CH3:22][O:23][C:24]1[CH:29]=[CH:28][C:27]([O:30][CH3:31])=[CH:26][C:25]=1[C:32]1[C:33]([C:41]([OH:43])=[O:42])=[CH:34][C:35]([N+:38]([O-:40])=[O:39])=[CH:36][CH:37]=1

Participants

3

Reactant 2

HCID 10805422Methyl 2',5'-dimethoxy-4-nitro-2-biphenylcarboxylateHCID 234336025'-Fluoro-2'-methoxy-4-nitro-2-biphenylcarboxylic acid

Product 1

HCID 234334422',5'-Dimethoxy-4-nitro-2-biphenylcarboxylic acidYield 99%

Procedure

This compound was prepared in a manner similar to that of 5'-fluoro-2'-methoxy-4-nitro-2-biphenylcarboxylic acid (EXAMPLE 107) from methyl 2',5'-dimethoxy-4-nitro-2-biphenylcarboxylate (2.07 g) to afford 1.93 g (99%) of 2',5'-dimethoxy-4-nitro-2-biphenylcarboxylic acid as a white solid. Data for 2',5'-dimethoxy-4-nitro-2-biphenylcarboxylic acid; 1H NMR (400 MHz, acetone-d6) 8.64 (d, J=2.5, 1 H), 8.43 (dd, J=8.4, 2.6, 1 H), 7.67 (d, J=8.5, 1 H), 6.94 (m, 2 H), 3.80 (s, 3 H), 3.68 (s, 3 H).

Sources & evidence

ORD record
ord-02d017026cb54bb88636806018f4e650
Source dataset
uspto-grants-2000_07
Patent number
US06093821

Reaction notes

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