4-Nitro-1,3-dihydroisobenzofuran → 4-Amino-1,3-dihydroisobenzofuran

HRID 2290113Notes

Reaction equation

HRID 2290113 reaction equation
[N+:1]([C:4]1[CH:12]=[CH:11][CH:10]=[C:9]2[C:5]=1[CH2:6][O:7][CH2:8]2)([O-])=O.[H][H]>[Pd]>[NH2:1][C:4]1[CH:12]=[CH:11][CH:10]=[C:9]2[C:5]=1[CH2:6][O:7][CH2:8]2

Participants

4

Reactant 2

HCID 134722514-Nitro-1,3-dihydroisobenzofuranHCID 178418361HCID 178418361, compound

Product 1

HCID 134722524-Amino-1,3-dihydroisobenzofuran

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

Nitration of the 1,3-dihydro-iso-benzofuran derivatives of Formula 17 provides the 1,3-dihydro-4-nitro-iso-benzofuran compounds of Formula 18. The nitro compounds of Formula 18 are reduced with hydrogen on a suitable catalyst, such as palladium, to give the 1,3-dihydro-4-amino-iso-benzofuran compounds of Formula 19.

Sources & evidence

ORD record
ord-7e05cede79f142458dc3fb56cac26c49
Source dataset
uspto-grants-2000_07
Patent number
US06093838

Reaction notes

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