Dichloromethane → HCID 20231876, compound

HRID 2290195Notes

Reaction equation

HRID 2290195 reaction equation
[NH:1]([C:3]([O:5]C)=[O:4])[NH2:2].[CH3:7][N:8]=[C:9]=[S:10].[CH2:11](Cl)Cl>>[CH3:11][N:1]([C:3]([OH:5])=[O:4])[NH:2][C:9]([NH:8][CH3:7])=[S:10]

Participants

4

Reactant 3

HCID 6344Dichloromethane2×HCID 11167Methyl isothiocyanateHCID 80519Methyl carbazate

Product 1

HCID 20231876HCID 20231876, compound

Conditions

Temperature
40 °C

Procedure

To a stirred mixture of 20 g (0.22, 0.2 mole) methyl hydrazinocarboxylate in 150 ml methylene chloride, 14.6 g (0.2 mole) methyl isothiocyanate in 50 ml methylene chloride was added dropwise. The reaction mixture was refluxed at about 40° C. for 0.5 hour, was allowed to stir overnight at ambient temperature, and was refluxed an additional 2 hours. The reaction mixture was cooled, vacuum filtered and the solids were dried to give 27.2 g of the above-identified product.

Workup

  1. additionwas added dropwise
  2. temperaturewas refluxed an additional 2 hours
  3. temperatureThe reaction mixture was cooled
  4. filtrationvacuum filtered
  5. customthe solids were dried

Sources & evidence

ORD record
ord-3f065072038a4c96a6627cd53c49aea8
Source dataset
uspto-grants-1986_10
Patent number
US04616004

Reaction notes

Loading…