Acetic Acid → 1,3-Dihydro-7,8-dimethoxy-2H-3-benzazepin-2-one

HRID 2290210Notes

Reaction equation

HRID 2290210 reaction equation
CO[CH:3](OC)[CH2:4][NH:5][C:6](=[O:18])[CH2:7][C:8]1[CH:13]=[CH:12][C:11]([O:14][CH3:15])=[C:10]([O:16][CH3:17])[CH:9]=1.C(O)(=O)C>Cl>[CH3:15][O:14][C:11]1[C:10]([O:16][CH3:17])=[CH:9][C:8]2[CH2:7][C:6](=[O:18])[NH:5][CH:4]=[CH:3][C:13]=2[CH:12]=1

Participants

4

Reactant 2

HCID 176Acetic AcidHCID 13092500n-(2,2-Dimethoxyethyl)-2-(3,4-dimethoxyphenyl)acetamide

Product 1

HCID 14823731,3-Dihydro-7,8-dimethoxy-2H-3-benzazepin-2-one

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A solution of 600.6 gm of N-(2,2-dimethoxyethyl)-3,4-dimethoxy-phenylacetamide in 3 liters of concentrated hydrochloric acid is mixed with 3 liters of glacial acetic acid. After standing for 17 hours at ambient temperature, the mixture is poured onto ice. The crystals precipitated are subjected to suction filtration, washed with water until neutral, and dried.

Workup

  1. additionthe mixture is poured onto ice
  2. customThe crystals precipitated
  3. filtrationare subjected to suction filtration
  4. washwashed with water until neutral, and
  5. customdried

Sources & evidence

ORD record
ord-73a98a539b8c4e1ea789f6228dcd1343
Source dataset
uspto-grants-1986_10
Patent number
US04616011

Reaction notes

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