反应详情

A mixture of diethyl (4-phenylbutyl)phosphonate (3.5 g, 13.0 mmole) and 6N HCl (45 ml) was refluxed under argon for 16 hours. The cooled reaction mixture was extracted with EtOAc. The organic phase was washed with saturated NaCl, dried (MgSO4), and evaporated. The crude product (2.3 g) was recrystallized from diisopropyl ether to give pure (4-phenylbutyl)phosphonic acid (1.7 g, 61%) as white needles, m.p. 92°-93° C.

1. temperaturewas refluxed under argon for 16 hours
2. customThe cooled reaction mixture
3. extractionwas extracted with EtOAc
4. washThe organic phase was washed with saturated NaCl
5. dry with materialdried (MgSO4)
6. customevaporated
7. customThe crude product (2.3 g) was recrystallized from diisopropyl ether