反应详情

2.93 g of 4-(1-methyltetrazol-5-ylthio)-butyric acid ethyl ester are dissolved in 50 ml of THF, 15 ml of 1N NaOH are added and the whole is stirred for 3 hours at room temperature. Most of the THF is then concentrated by evaporation under reduced pressure in a rotary evaporator and the residue is washed with ethyl acetate. The aqueous solution is adjusted to pH 3 with 4N HCl and extracted three times with ethyl acetate. After drying over sodium sulphate and concentration by evaporation under reduced pressure, the pure title compound is obtained.

1. concentrationMost of the THF is then concentrated by evaporation under reduced pressure in a rotary evaporator
2. washthe residue is washed with ethyl acetate
3. extractionextracted three times with ethyl acetate
4. dry with materialAfter drying over sodium sulphate and concentration by evaporation under reduced pressure