Thionyl Chloride → HCID 15098931, compound

HRID 2290233Notes

Reaction equation

HRID 2290233 reaction equation
[CH3:1][N:2]1[C:6]([S:7][CH2:8][CH2:9][CH2:10][C:11]([OH:13])=O)=[N:5][N:4]=[N:3]1.S(Cl)([Cl:16])=O>C1C=CC=CC=1.CN(C=O)C>[CH3:1][N:2]1[C:6]([S:7][CH2:8][CH2:9][CH2:10][C:11]([Cl:16])=[O:13])=[N:5][N:4]=[N:3]1

Participants

5

Reactant 2

HCID 24386Thionyl ChlorideHCID 130916224-[(1-Methyl-1H-tetrazol-5-yl)sulfanyl]butanoic acid

Product 1

HCID 15098931HCID 15098931, compound

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideCatalystHCID 241BenzeneSolvent

Procedure

2.2 g of 4-(1-methyltetrazol-5-ylthio)-butyric acid are stirred in 20 ml of absolute benzene with 1.03 ml of thionyl chloride and 4 drops of DMF for 20 minutes at the reflux temperature. The solvent is then concentrated by evaporation under reduced pressure. After dissolving and concentrating by evaporation twice more in toluene, the pure title compound is obtained in the form of a yellow oil.

Workup

  1. concentrationThe solvent is then concentrated by evaporation under reduced pressure
  2. dissolutionAfter dissolving
  3. concentrationconcentrating by evaporation twice more in toluene

Sources & evidence

ORD record
ord-7ff13846860e4002b9df64feb5c537e8
Source dataset
uspto-grants-1986_10
Patent number
US04616007

Reaction notes

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