1-Acetylpiperazine → HCID 45262550, compound

HRID 2290242Notes

Reaction equation

HRID 2290242 reaction equation
[Cl:1][C:2]1[N:11]=[C:10]2[C:5]([C:6](=[O:21])[C:7]([C:18]([OH:20])=[O:19])=[CH:8][N:9]2[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[CH:4][C:3]=1[F:22].[C:23]([N:26]1CC[NH:29][CH2:28][CH2:27]1)(=O)[CH3:24]>>[ClH:1].[C:12]1([N:9]2[C:10]3[C:5](=[CH:4][C:3]([F:22])=[C:2]([N:26]4[CH2:23][CH2:24][CH:28]([NH2:29])[CH2:27]4)[N:11]=3)[C:6](=[O:21])[C:7]([C:18]([OH:20])=[O:19])=[CH:8]2)[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

Participants

3

Reactant 2

HCID 837951-AcetylpiperazineHCID 137153157-Chloro-6-fluoro-4-oxo-1-phenyl-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid

Product 1

HCID 45262550HCID 45262550, compound

Procedure

In the described fashion as Example 1(f) the above ester (III) reacting with N-acetylpiperazine can give the desired 1-p-fluorophenyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-1,8-naphthyridine-3-carboxylic acid (I) ##STR28## and its hydrochloride salt.

Sources & evidence

ORD record
ord-800c4fa06f9e425a89e4444da0b0e21d
Source dataset
uspto-grants-1986_10
Patent number
US04616019

Reaction notes

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