HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzene → 6-[4-(2-furylmethylenamino)phenyl]-5-methyl-4,5-dihydro-1,2,4-triazin-3(2H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzene | HCID 241 | — |
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Furfural | HCID 7362 | — |
| Reactant | 6-(4-aminophenyl)-5-methyl-4,5-dihydro-1,2,4-triazin-3(2H)-one | HCID 13386033 | — |
| Solvent | Water | HCID 962 | — |
| Product | 6-[4-(2-furylmethylenamino)phenyl]-5-methyl-4,5-dihydro-1,2,4-triazin-3(2H)-one | HCID 20232150 | 89.3% |
Reaction Steps
A mixture of 6-(4-aminophenyl)-5-methyl-4,5-dihydro-1,2,4-triazin-3(2H)-one (2 g), furfural (1.41 g), DMF (25 ml) and benzene (25 ml) was refluxed in an apparatus equipped with a Dean-Stark water separator for 3 hours. The reaction mixture was evaporated in vacuo and the resultant residue was triturated with diethyl ether to give 6-[4-(2-furylmethylenamino)phenyl]-5-methyl-4,5-dihydro-1,2,4-triazin-3(2H)-one (2.47 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04616015 |
| Source dataset | uspto-grants-1986_10 |
| ORD ID | ord-ea02c8cf49e44528a64cd5560adbf37c |
| Source note | uspto-grants-1986_10 |