反应详情

A mixture of 6-(4-aminophenyl)-5-methyl-4,5-dihydro-1,2,4-triazin-3(2H)-one (2 g), furfural (1.41 g), DMF (25 ml) and benzene (25 ml) was refluxed in an apparatus equipped with a Dean-Stark water separator for 3 hours. The reaction mixture was evaporated in vacuo and the resultant residue was triturated with diethyl ether to give 6-[4-(2-furylmethylenamino)phenyl]-5-methyl-4,5-dihydro-1,2,4-triazin-3(2H)-one (2.47 g).

1. temperaturewas refluxed in an apparatus
2. customThe reaction mixture was evaporated in vacuo
3. customthe resultant residue was triturated with diethyl ether