Hydrochloric Acid → HCID 20232136, compound

HRID 2290274Notes

Reaction equation

HRID 2290274 reaction equation
[N:1]([O-])=O.[Na+].Cl.[NH:6]([C:8]1[CH:13]=[CH:12][C:11]([C:14]2[CH:15]([CH3:21])[NH:16][C:17](=[O:20])[NH:18][N:19]=2)=[CH:10][CH:9]=1)[NH2:7].Cl>O>[N:6]([C:8]1[CH:9]=[CH:10][C:11]([C:14]2[CH:15]([CH3:21])[NH:16][C:17](=[O:20])[NH:18][N:19]=2)=[CH:12][CH:13]=1)=[N+:7]=[N-:1]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 20232164HCID 20232164, compoundHCID 23668193Sodium Nitrite

Product 1

HCID 20232136HCID 20232136, compoundYield 67.6%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

A solution of sodium nitrite (0.3 g) in water (2 ml) was added dropwise to a solution of 6-(4-hydrazinophenyl)-5-methyl-4,5-dihydro-1,2,4-triazin-3(2H)-one hydrochloride (0.92 g) in a mixture of 1N-hydrochloric acid (3 ml) and water (20 ml) under ice cooling. After stirring for 30 minutes, the resultant precipitates were collected by filtration and washed successively with water, methanol and diisopropyl ether to give 0.56 g of 6-(4-azidophenyl)-5-methyl-4,5-dihydro-1,2,4-triazin-3(2H)-one.

Workup

  1. customthe resultant precipitates
  2. filtrationwere collected by filtration
  3. washwashed successively with water, methanol and diisopropyl ether

Sources & evidence

ORD record
ord-1eb951847c614abda19f19e7835eb62c
Source dataset
uspto-grants-1986_10
Patent number
US04616015

Reaction notes

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