Hydrochloric Acid → HCID 136332164, compound

HRID 2290278Notes

Reaction equation

HRID 2290278 reaction equation
[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15](=O)[C:16](=[N:18][OH:19])[CH3:17])=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH2:21][NH:22][C:23]([NH2:25])=[S:24].Cl>CO>[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15](=[N:21][NH:22][C:23]([NH2:25])=[S:24])[C:16](=[N:18][OH:19])[CH3:17])=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 2723789ThiosemicarbazideHCID 713505261-[4-(Benzyloxy)phenyl]-2-(hydroxyimino)propan-1-one

Product 1

HCID 136332164HCID 136332164, compoundYield 66.7%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

A mixture of 4'-benzyloxy-2-hydroxyiminopropiophenone (21.1 g), thiosemicarbazide (7.15 g), methanol (107 ml) and a saturated solution of hydrogen chloride in methanol (2 ml) was refluxed for 65 minutes with stirring. After cooling, the resultant precipitates were collected by filtration, washed successively with methanol, water and methanol, and then dried to give 17.9 g of 4'-benzyloxy-2-hydroxyiminopropiophenone thiosemicarbazone.

Workup

  1. temperatureAfter cooling
  2. customthe resultant precipitates
  3. filtrationwere collected by filtration
  4. washwashed successively with methanol, water and methanol
  5. customdried

Sources & evidence

ORD record
ord-2c9a8ccef5464f3093c1000fdbb0fc17
Source dataset
uspto-grants-1986_10
Patent number
US04616015

Reaction notes

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