Ethanol → Indoline-2-carboxylic acid
Reaction equation
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][CH2:2]1.[CH2:10]([OH:12])C.[OH-:13].[Na+]>>[C:10]([CH:2]1[CH2:3][C:4]2[C:9](=[CH:8][CH:7]=[CH:6][CH:5]=2)[NH:1]1)([OH:12])=[O:13]Participants
4
Procedure
31.5 g of the above indoline (86%) are obtained by saponification in 250 ml of normal sodium hydroxide solution and 150 ml of ethanol for 18 hours at room temperature of 43 g (0.224 mol) of the corresponding ethyl ester prepared according to E. J. COREY et al. (J. Amer. Chem. Soc. 1970 92, p. 2476).
Sources & evidence
- ORD record
- ord-eebb28af16804b82bf969b74f83e5a8b
- Source dataset
- uspto-grants-1986_10
- Patent number
- US04616029
Reaction notes
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