Hydrochloric Acid → HCID 20232060, compound

HRID 2290333Notes

Reaction equation

HRID 2290333 reaction equation
[CH3:1][C:2]1[N:3]=[C:4]([N:14]2[CH2:19][CH2:18][O:17][CH2:16][CH2:15]2)[N:5]=[N:6][C:7]=1[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1.[ClH:20]>C(O)C.[Pd]>[ClH:20].[CH3:1][CH:2]1[C:7]([C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=2)=[N:6][NH:5][C:4]([N:14]2[CH2:19][CH2:18][O:17][CH2:16][CH2:15]2)=[N:3]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 20232025HCID 20232025, compound

Product 1

HCID 20232060HCID 20232060, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

5-Methyl-3-morpholino-6-phenyl-1,2,4-triazine (2.32 g) was dissolved in ethanol (40 ml) containing anhydrous hydrogen chloride and hydrogenated over 10% palladium on carbon (0.33 g) under an atmospheric pressure at room temperature. After the theoretical amount of hydrogen gas was absorbed, the catalyst was filtered off, and the filtrate was evaporated under reduced pressure. The residual solid was recrystallized from ethanol to give crystals of 5-methyl-3-morpholino-6-phenyl-2,5-dihydro-1,2,4-triazine hydrochloride, mp 213°~215.5° C.

Workup

  1. customAfter the theoretical amount of hydrogen gas was absorbed
  2. filtrationthe catalyst was filtered off
  3. customthe filtrate was evaporated under reduced pressure
  4. customThe residual solid was recrystallized from ethanol

Sources & evidence

ORD record
ord-25216b771d3d401c9dcab765c9909aa1
Source dataset
uspto-grants-1986_10
Patent number
US04616014

Reaction notes

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