反应详情

Formic acid (5 ml) was added dropwise to acetic anhydride (10 ml) with stirring under ice cooling, and stirred at 50° C. for 15 minutes. To the solution was added 3-hydrazino-5-methyl-6 -phenyl-1,2,4-triazine (5g) with stirring under ice cooling, and the stirring was continued for 50 minutes under ice cooling. The reaction mixture was poured into ice water, and the resultant precipitates were collected by filtration and washed with water. The above obtained solid was dissolved in methanol (100 ml), the solution was treated with 28% ammonium hydroxide (14 drops) and evaporated to give white powder of 3-(2-formylhydrazino)-5-methyl-6-phenyl-1,2,4-triazine (4.505 g).

1. stirringstirred at 50° C. for 15 minutes
2. stirringwith stirring under ice cooling
3. customthe resultant precipitates
4. filtrationwere collected by filtration
5. washwashed with water
6. customThe above obtained solid
7. customevaporated